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Background/aims Increased carotid intima–media thickness (CIMT) was shown to be an independent predictor of cardiovascular (CV) mortality in dialysis patients and the general population. Growth differentiation factor 15 (GDF-15), a member of the transforming growth factor superfamily, is produced by cardiomyocytes and atherosclerotic lesions under stress conditions such as inflammation. We assessed...
Sportler und insbesondere Leistungssportler sind meist junge Menschen, mit denen kein erhöhtes Gesundheitsrisiko, es sei denn für Traumata, assoziiert wird. Es kommt aber signifikant häufiger zu Fällen des plötzlichen Herztodes (PHT) in dieser Gruppe. Die Inzidenz des PTH bei Sportlern bewegt sich zwischen 0,6 und 3,0/100.000 pro Jahr. Häufig ist der PHT hier das erste Erscheinungsbild einer zugrunde...
Die koronare Herzkrankheit ist die häufigste Todesursache weltweit. Körperliche Inaktivität und eingeschränkte körperliche Leistungsfähigkeit sind für 9% der Fälle einer verfrühten Mortalität verantwortlich. Im Gegenzug führt regelmäßige körperliche Aktivität zu einer Steigerung der kardiopulmonalen Fitness, und beides wirkt sich positiv auf die kardiovaskuläre Morbidität und Mortalität aus, indem...
Aims In earlier studies, we reported structural remodeling was associated with atrial fibrillation (AF) and showed that the renin–angiotensin–aldosterone system (RAAS) was linked to AF. It is reasonable to hypothesize that there is a cycle, from RAAS to structural remodeling to AF. Patients and methods Our study group consisted of 80 patients scheduled for mitral valve replacement surgery. Tissue...
Objective Preintervention thrombus burden in the infarct-related artery is an independent predictor of no-reflow and adverse outcomes in coronary artery disease. The role of D-dimers in the acute phase of ST-elevated myocardial infarction (STEMI) during primary percutaneous coronary intervention (PCI) has not been fully elucidated. We aimed to investigate the predictive value of serum D-dimer levels...
Aim The purpose of this work was to evaluate epicardial adipose tissue (EAT), carotid intima–media thickness (CIMT), and flow-mediated dilatation (FMD) of the brachial artery in rheumatoid arthritis (RA) patients using ultrasonographic methods. Interrelationships between these three parameters in RA patients were also investigated. Methods EAT thickness, CIMT, and FMD were measured by ultrasonography...
Background Coronary microvascular impairment may cause myocardial ischemia and systolic dysfunction in patients with idiopathic dilated cardiomyopathy (IDC). Patients and methods The study included 41 patients with IDC and 33 healthy control subjects. Serum total antioxidant status (TAS), serum interleukin (IL)-6 levels, and tumor necrosis factor (TNF)-α levels were assayed and coronary flow reserve...
Doping, d. h. insbesondere der Missbrauch von anabol-androgenen Steroiden, ist kein ausschließliches Problem im professionellen Sport, sondern auch im Breiten- und Freizeitsport weit verbreitet. Vor allem exzessive Überdosierungen anaboler Steroide, wie sie im Kraftsport und Bodybuilding sicher belegt sind, führen zu gravierenden Nebenwirkungen. Neben endokrinen Nebenwirkungen sind vor allem kardiovaskuläre...
Background Prosthetic valve thrombosis (PVT) is serious complication of valvular replacement surgery, and increased levels of anticardiolipin antibodies (aCL) are associated with thrombosis. The aim of this study was to evaluate the role of aCL in the development of PVT. Patients and methods We studied the aCL IgM and IgG levels in 114 patients with PVT and 80 healthy patients with prosthetic valves...
Background The emerging term “visceral adiposity index (VAI)” was reported to be closely correlated with glycemic disturbances and diabetes risk. However, whether VAI could predict future type 2 diabetes mellitus (DM) is unknown. Here, we aimed to assess the predictive value of VAI for DM in a Chinese population via a prospective cohort study. Patients and methods This prospective cohort study was...
Background Upon coincubation with platelet aggregates, CD34+ progenitor cells have the potential to differentiate into foam cells. There is evidence that progenitor cells from diabetic and nondiabetic patients have different properties, which may affect the patients’ prognosis. In this study we investigated an in vitro model of foam cell formation based on patient-derived CD34+ progenitor cells. We...
Aims Atherosclerosis is a systemic disease that can affect the whole arterial tree. An important cause of neuronal degeneration is atherosclerosis, which may lead to sensorineural hearing loss. We aimed to investigate the relationship between the angiographic severity and extent of coronary artery disease, which is a surrogate of atherosclerotic burden, and the degree of sensorineural hearing loss...
Background The median dose area products (DAP) and effective doses (ED) of patients arising from coronary angiography (CA) are considerable: According the 2013 National German Registry, they amount to 19.8 Gy × cm2 and 4.0 mSv, respectively. Methods We investigated the feasibility of prospective electrocardiogram (ECG)-gated coronary angiography (CA)—a novel technique in invasive cardiology—with...
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